DNA photodamage recognition by RNA polymerase II.
نویسندگان
چکیده
During gene transcription, RNA polymerase (Pol) II encounters obstacles, including lesions in the DNA template. Here, we review a recent structure-function analysis of Pol II transcribing DNA with a bulky photo-lesion in the template strand. The study provided the molecular basis for recognition of a damaged DNA by Pol II, which is the first step in transcription-coupled DNA repair (TCR). The results have general implications for damage recognition and the TCR mechanism.
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عنوان ژورنال:
- FEBS letters
دوره 581 15 شماره
صفحات -
تاریخ انتشار 2007